By John S. Bradley MD, John D. Nelson MD Emeritus
Read Online or Download 2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial Therapy PDF
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Extra info for 2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial Therapy
Indd 44 Pertussis109,110 Azithromycin (10 mg/kg/day x 5 d) or clarithromycin Azithromycin and clarithromycin are better tolerated than (15 mg/kg/day div bid x 7 d) or erythromycin erythromycin (Chapter 5); azithromycin is preferred in (estolate preferable) young infants to reduce pyloric stenosis risk 40 mg/kg/day PO div qid; x 14 d (AII) The azithromycin dosage that is recommended for infants Alternative: TMP/SMX (8 mg/kg/day TMP) div bid x <1 month of age, but this dosage is well tolerated and 14 d (BIII) safe for older children (12 mg/kg/day X 5 d is actually FDA approved for other indications).
35,36 streptococcus); K kingae For pen-S pneumococci or group A streptococcus: penicillin G 200,000 U/kg/day IV div q6h For pen-R pneumococci or Haemophilus: ceftriaxone 50–75 mg/kg/day IV, IM q24h, OR cefotaxime (BII) Comments See Chapter 4 for additional information on CA-MRSA. B. SKELETAL INFECTIONS Clinical Diagnosis Skeletal Infections — 35 1/28/10 3:08 PM See Chapter 5. – Newborn See Chapter 7 for preferred antibiotics. 5 mg/kg/day IM, IV div q8h (BIII); procedure needed in at least 20% of children); oral puncture wound) OR cefepime 150 mg/kg/day IV div q8h (BIII); OR convalescent therapy with ciprofloxacin (BIII)46 P aeruginosa (occasionally meropenem 60 mg/kg/day IV div q8h (BIII); ADD Treatment course 7–10 d after surgery S aureus, including CA-MRSA) vancomycin 40 mg/kg/day IV q8h for serious infection (for CA-MRSA), pending culture results For MSSA: dicloxacillin 75–100 mg/kg/day PO div qid Surgery to debride sequestrum is usually required for – Chronic (staphylococcal)46 OR cephalexin 100–150 mg/kg/day PO div tid x cure.
Critical evaluations of duration of therapy have been carried out in very few diseases. In general, a longer duration of therapy should be used (1) for tissues in which antibiotic concentrations may be relatively low (eg, abscess, bone), (2) when the organisms are less susceptible, (3) when a relapse of infection is unacceptable (eg, CNS infections), or (4) when the host is immune-compromised in some way. An assessment after therapy will ensure that your selection of antibiotic, dose, and duration of therapy was appropriate.
2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial Therapy by John S. Bradley MD, John D. Nelson MD Emeritus